Thermo Fisher Scientific HDAC9 Monoclonal Antibody (OTI6E2), TrueMAB
HDAC9 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot 및 IHC(P) 분석에 적합. Human 시료 반응성. 무보존제, 동결건조 형태로 제공되며 재구성 후 1 mg/mL 농도 유지. 크로마틴 조절 연구 및 탈아세틸화 효소 기능 분석에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 181–460 of human HDAC9 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is essential for transcriptional regulation, with histone acetylation playing a major role. Acetylation of lysine residues in histone tails induces conformational changes that enhance DNA accessibility to transcription factors.
Histone deacetylases (HDACs) reverse this process, leading to transcriptional silencing. HDAC9 and HDAC9a are alternatively spliced isoforms, both retaining deacetylase activity and repressing myocyte enhancer-binding factor 2-mediated transcription. These isoforms are expressed in brain, skeletal muscle, kidney, placenta, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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