Thermo Fisher Scientific SCNN1G Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
CNINPYKYST VRHLLADLEQ ETREALKSLY GFPESRKRRE AESWNSVSEG KQPRFSHRIP LLIFDQDEKG KARDFFTGRK RKVGGSIIHK ASNVMHIESK QVVGFQLCSN DTSDCATYTF SSGINAIQEW YKLHYMNIMA QVPLEKKINM S

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarities, including two intracellular termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
ENaC consists of three homologous isoforms: alpha, beta, and gamma. It plays a key role in sodium and fluid balance in the kidney, lung, and colon, and mediates aldosterone-dependent sodium reabsorption in the distal nephron, thus regulating blood pressure.
Mutations in ENaC subunits are linked to disorders such as Liddle’s syndrome (gain-of-function) and pseudohypoaldosteronism type I (loss-of-function).

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.