Thermo Fisher Scientific SCNN1G Polyclonal Antibody
SCNN1G 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat 반응성. Affinity Chromatography로 정제된 액상 항체이며, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 100–250 of human SCNN1G (NP_001030.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.09 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855758 |
Product Specific Information
Immunogen sequence:
CNINPYKYST VRHLLADLEQ ETREALKSLY GFPESRKRRE AESWNSVSEG KQPRFSHRIP LLIFDQDEKG KARDFFTGRK RKVGGSIIHK ASNVMHIESK QVVGFQLCSN DTSDCATYTF SSGINAIQEW YKLHYMNIMA QVPLEKKINM S
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarities, including two intracellular termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
ENaC consists of three homologous isoforms: alpha, beta, and gamma. It plays a key role in sodium and fluid balance in the kidney, lung, and colon, and mediates aldosterone-dependent sodium reabsorption in the distal nephron, thus regulating blood pressure.
Mutations in ENaC subunits are linked to disorders such as Liddle’s syndrome (gain-of-function) and pseudohypoaldosteronism type I (loss-of-function).
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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