Thermo Fisher Scientific LARGE Monoclonal Antibody (LARGE-02)
인간 LARGE1 단백질을 인식하는 mouse IgG2b 단클론 항체로, Western blot 및 유세포분석에 사용 가능. Protein A 정제, PBS buffer에 1 mg/mL 농도로 제공. 연구용으로만 사용되며 4°C 보관 권장.
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LARGE-02 |
| Immunogen | Human LARGE1 (amino acids 35–142) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745570 |
Additional Formats
Product Specific Information
This antibody recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus. Cross-reactivity with LARGE2 was not determined.
Target Information
The LARGE gene, one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase family. It participates in glycosylation of alpha-dystroglycan and may synthesize glycoprotein and glycosphingolipid sugar chains. Mutations cause MDC1D, a congenital muscular dystrophy with mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing produces two transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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