Thermo Fisher Scientific SPAG1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human SPAG1 recombinant protein. Suitable for research on spermatogenesis and fertilization mechanisms. Supplied as liquid at 0.1 mg/mL, stored at 4°C short term or -20°C long term. For research use only.
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- PA554879
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Thermo Fisher Scientific SPAG1 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SPAG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647772 |
Product Specific Information
Immunogen sequence:
PSIIEAKMEL EEVTRLLNLK DKTAPFNKEK ERRKIEIQEV NEGKEEPGRP AGEVSTGCLA SEKGGKSSRS PEDPEKLPIA KPNNAYEFGQ IINALST
Highest antigen sequence identity to the following orthologs:
- Mouse: 42%
- Rat: 41%
Target Information
Anti-sperm antibodies have been correlated with cases of unexplained infertility, suggesting a role in blocking fertilization. The identification and characterization of sperm antigens are important for understanding immunologic infertility and developing targeted contraception.
The protein encoded by the SPAG1 gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Immunization of female rats with recombinant human SPAG1 protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa.
Recombinant SPAG1 binds GTP and exhibits GTPase activity, indicating a role in GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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