Thermo Fisher Scientific CD273 (B7-DC) Polyclonal Antibody
Human PD-L2(CD273, B7-DC)에 특이적인 Rabbit Polyclonal Antibody. IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품이며, 고순도와 안정성을 제공. 연구용으로 면역 체크포인트 관련 연구에 적합.
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Thermo Fisher Scientific CD273 (B7-DC) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PDCD1LG2. Recombinant protein control fragment (Product #RP-90599). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789642 |
Product Specific Information
Immunogen sequence:
GYPLAEVSWP NVSVPANTSH SRTPEGLYQV TSVLRLKPPP GRNFSCVFWN THVRELTLAS IDLQSQMEPR THPT
Target Information
Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. It acts as a ligand for PD-1 along with PD-L1 and plays an important role in immune checkpoint regulation. PD-L2 is primarily expressed in dendritic cells but can be induced in various cell types depending on the microenvironment.
PD-L2 expression is upregulated by cytokines such as IL-4, TNF-alpha, and IFN-gamma. Compared to PD-L1, PD-L2 shows higher affinity to PD-1 (2–6×). It contributes to immune homeostasis by inhibiting T cell activation and cytokine secretion.
Recent studies revealed PD-L2 also binds to RGMb, regulating respiratory tolerance through BMP/neogenin signaling pathways. The human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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