Thermo Fisher Scientific CD42b Polyclonal Antibody
인체 CD42b 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC(P)에서 1:200~1:500 희석으로 사용 가능. 혈소판 활성화 및 응고 과정 연구에 적합하며, 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Thermo Fisher Scientific CD42b Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GP1BA. Recombinant protein control fragment (Product #RP-90550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789638 |
Product Specific Information
Immunogen sequence:
SHLLPFAFLH GNPWLCNCEI LYFRRWLQDN AENVYVWKQG VDVKAMTSNV ASVQCDNSDK FPVYKYPGKG CPTLGDEGDT DLYDYYPEED TEGDKVRATR TVVKFPTKAH TTPWGLFYSW STASLDSQMP SSLHPTQEST KEQTT
Target Information
CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface.
CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1 and P-selectin.
The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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