Thermo Fisher Scientific Phospho-MKP1/MKP2 (Ser296, Ser318) Polyclonal Antibody
Phospho-MKP1/MKP2 (Ser296, Ser318) 폴리클로날 항체로 MKP-1/2 인산화 부위 특이적 검출에 적합. Western blot 및 IHC(P) 응용 가능. Rabbit IgG 기반 비결합형 액상 항체로 -20°C 보관. 연구용으로만 사용.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-MKP1/MKP2 (Ser296, Ser318) Polyclonal Antibody
Thermo Fisher Scientific Phospho-MKP1/MKP2 (Ser296, Ser318) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human MKP-1/2 around the phosphorylation site of Ser296/318 (I-I-SP-P-N) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556346 |
Target Information
Mitogen-activated protein kinase phosphatases (MKPs) are negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that dephosphorylates and inactivates MAPKs such as ERK, JNK, and p38. It contains one Rhodanese domain and one tyrosine-protein phosphatase domain, is expressed in various tissues, and localizes in the nucleus. Transcription factor E2F-1 regulates MKP2 expression, and the E2F-1/MKP2 pathway mediates apoptosis under oxidative stress. MKP2 suppresses tumor formation and is a transcriptional target of p53 through a 10-bp palindrome motif (CTGGCGCCAG) in its promoter.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.