Thermo Fisher Scientific Phospho-MKP1/MKP2 (Ser296, Ser318) Polyclonal Antibody
Phospho-MKP1/MKP2 (Ser296, Ser318) 폴리클로날 항체로 MKP-1/2 인산화 부위 특이적 검출에 적합. Western blot 및 IHC(P) 응용 가능. Rabbit IgG 기반 비결합형 액상 항체로 -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-MKP1/MKP2 (Ser296, Ser318) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human MKP-1/2 around the phosphorylation site of Ser296/318 (I-I-SP-P-N) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556346 |
Target Information
Mitogen-activated protein kinase phosphatases (MKPs) are negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that dephosphorylates and inactivates MAPKs such as ERK, JNK, and p38. It contains one Rhodanese domain and one tyrosine-protein phosphatase domain, is expressed in various tissues, and localizes in the nucleus. Transcription factor E2F-1 regulates MKP2 expression, and the E2F-1/MKP2 pathway mediates apoptosis under oxidative stress. MKP2 suppresses tumor formation and is a transcriptional target of p53 through a 10-bp palindrome motif (CTGGCGCCAG) in its promoter.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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