Thermo Fisher Scientific MRPS12 Polyclonal Antibody
Rabbit polyclonal antibody against human MRPS12 protein. Validated for Western blot and ELISA. Provides high specificity and sensitivity for mitochondrial ribosomal protein detection. Supplied as a liquid, affinity-purified, stored in PBS with glycerol...
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 30–138 of human MRPS12 (NP_203527.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.82 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913668 |
Product Specific Information
- Positive test controls: LO2, U-251MG, HT-29, 293T
- Subcellular localization: Mitochondrion
- Immunogen sequence:
MATLNQMHRL GPPKRPPRKL GPTEGRPQLK GVVLCTFTRK PKKPNSANRK CCRVRLSTGR EAVCFIPGEG HTLQEHQIVL VEGGRTQDLP GVKLTVVRGK YDCGHVQKK
Target Information
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and are essential for mitochondrial protein synthesis. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S and a large 39S subunit, with approximately 75% protein to rRNA ratio. Unlike prokaryotic ribosomes, mitoribosomes lack 5S rRNA. The MRPS12 gene encodes a 28S subunit protein of the ribosomal protein S12P family, crucial for decoding fidelity and aminoglycoside antibiotic susceptibility. It is located near the mitochondrial seryl-tRNA synthetase gene, both considered candidates for autosomal dominant deafness (DFNA4). Splice variants differing in the 5′ UTR encode the same protein.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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