Thermo Fisher Scientific IL1F6 Recombinant Rabbit Monoclonal Antibody (112)

Applications

• ELISA (ELISA): 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Human IL-1F6.

Target Information

The IL-1 family comprises 11 structurally related ligands, including IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9).
IL-36α is highly expressed in psoriatic plaques and is the only IL-1 family member expressed by T cells, as well as monocytes and B cells. It is primarily found in skin and lymphoid tissues and to a lesser extent in fetal brain, trachea, stomach, and intestine.

IL-36α signals through IL-1Rrp2 (IL-1R6) and IL-RAcP (IL-1 receptor accessory protein), acting as an agonist of NF-κB and MAPK pathways, inducing proinflammatory cytokines and chemokines such as IL-6, IL-8, BD-2, and BD-3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.