Thermo Fisher Scientific WNT4 Polyclonal Antibody
WNT4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat에 반응하며, Protein A로 정제된 고품질 항체. KLH-conjugated synthetic peptide(aa 201–300)를 면역원으로 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human WNT4 (amino acids 201–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The WNT gene family encodes secreted signaling proteins involved in oncogenesis and developmental processes such as cell fate regulation and embryonic patterning.
WNT4 is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein sharing 98% amino acid identity with mouse and rat Wnt4.
WNT4, together with a nuclear receptor that antagonizes testis-determining factors, regulates female development and prevents testes formation.
Additionally, WNT4, WNT2, and WNT7B may be associated with abnormal proliferation in breast tissue.
Mutations in WNT4 can lead to Rokitansky-Kuster-Hauser syndrome and SERKAL syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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