Thermo Fisher Scientific Cytokeratin 14 Monoclonal Antibody (2F11)

Applications and Tested Dilutions

Product Specifications

Target Information

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (e.g., skin) and non-keratinizing cells (e.g., mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes: type I (acidic polypeptides) and type II (basic polypeptides).
Keratin 14 belongs to the type I subfamily of low molecular weight keratins and, in combination with keratin 5, distinguishes stratified epithelial cells from simple epithelial cells. It is useful in identifying squamous cell carcinomas and is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.