Thermo Fisher Scientific CD27 Monoclonal Antibody (LG.3A10)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Assay-dependent

Flow Cytometry (Flow)

• 0.5 µg/1×10⁶ cells
• View 1 publication

Product Specifications

Additional Formats

• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

MA5-17902 targets CD27/TNFRSF7 in FACS, IHC, and IHC (F) applications and shows reactivity with Mouse samples.
The MA5-17902 immunogen is mCD27 tag expressing clones AR0524 and AR0530.

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. TNF superfamily members regulate cell proliferation and death.
CD27 and its ligand CD70 are primarily expressed in lymphocytes. High CD27 expression depends on antigen receptor ligation, while CD70 expression requires co-stimulatory or pro-inflammatory signals.

CD27 exists as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and some B cells. Activation of T cells through the TCR-CD3 complex increases CD27 expression and releases soluble CD27 (sCD27, 28–32 kDa) detectable in plasma, urine, or spinal fluid. Soluble CD27 serves as a prognostic marker for B cell malignancies.
RgpA, a cysteine proteinase, degrades CD27 and counteracts T cell activation mediated by CD27-CD70. CD27-binding protein (SIVA) is a proapoptotic molecule involved in CD27-induced apoptosis.
Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.