Thermo Fisher Scientific TPL2 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 10 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Marmoset, Elephant, Bovine, Dog, Bat (100%)
Mouse, Rat, Hamster, Panda, Horse (94%)

Target Information

MAP3K8 (COT) is a serine/threonine kinase that activates both MAP and JNK kinase pathways and plays a role in the cell cycle.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
These kinases are highly conserved across species, including yeast, Drosophila, and mammals.
MEKK8 activates NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105.
This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines.
The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle.
The longer form undergoes phosphorylation mainly on Ser residues, and the shorter form on both Ser and Thr residues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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