Thermo Fisher Scientific TPL2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MAP3K8 (TPL2), reactive with multiple species. Suitable for IHC (Paraffin) at 10 µg/mL. Unconjugated, purified via antigen affinity chromatography. Supplied in PBS with sodium azide, stored at 4°C or -20°C.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Dog, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from near C-terminus of human MAP3K8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551282 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Marmoset, Elephant, Bovine, Dog, Bat (100%)
Mouse, Rat, Hamster, Panda, Horse (94%)
Target Information
MAP3K8 (COT) is a serine/threonine kinase that activates both MAP and JNK kinase pathways and plays a role in the cell cycle.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK.
These kinases are highly conserved across species, including yeast, Drosophila, and mammals.
MEKK8 activates NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105.
This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines.
The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle.
The longer form undergoes phosphorylation mainly on Ser residues, and the shorter form on both Ser and Thr residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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