Thermo Fisher Scientific THRB Recombinant Rabbit Monoclonal Antibody (6K1F1)
THRB 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot 및 ELISA에 적합하며 인간 시료에 반응. 고순도 친화 크로마토그래피 정제 및 안정한 PBS 기반 버퍼에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6K1F1 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–91 of human TR-beta 1/THRB (NP_000452.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.208 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093089 |
Product Specific Information
Immunogen sequence:
MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK NEQSSPHLIQ TTWTSSIFHL DHDDVNDQSV SSAQTFQTEE K
Target Information
Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to hormone response elements upon activation by thyroid hormones. These receptors regulate metabolic processes, growth, and development by controlling gene expression for growth hormone, malic enzyme, and hepatic proteins.
There are two main receptor forms: TR alpha (chromosome 17) and TR beta (chromosome 3), each with two isoforms (TRα1, TRα2, TRβ1, TRβ2). TRα1 and TRα2 share the same sequence up to amino acid 370, after which they diverge. TRα2, which does not bind T3, acts as a strong negative regulator of TR function. The gene encoding thyroid hormone receptor beta-1 is NR1A2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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