Thermo Fisher Scientific IL23R Recombinant Rabbit Monoclonal Antibody (5M2U3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:20,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5M2U3

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 510-629 of human IL23R (NP_653302.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IL23R,uniProtId:Q5VWK5-1,ncbiNodeId:9606,antigenRange:510-629,antigenLength:629,antigenImageFileName:MA5-51307_IL23R_Q5VWK5-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51307_IL23R_Q5VWK5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.073 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3093893

Product Specific Information

Immunogen sequence: KPPVDSLDSG NNPRLQKHPN FAFSVSSVNS LSNTIFLGEL SLILNQGECS SPDIQNSVEE ETTMLLENDS PSETIPEQTL LPDEFVSCLG IVNEELPSIN TYFPQNILES HFNRISLLEK

Target Information

IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.