Thermo Fisher Scientific EpCAM/CD326 (Epithelial Marker) Monoclonal Antibody (MOC-31)
인간 EpCAM/CD326 표적 단일클론 항체로, MOC-31 클론 사용. Western blot 및 면역조직화학(IHC) 등 다양한 응용 가능. 단백질 A/G로 정제된 액상 항체이며, PBS(pH 7.4)에 보존제 없이 제공. 연구용으로 인간 상피세포 및 암조직 표지에 적합.
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Thermo Fisher Scientific EpCAM/CD326 (Epithelial Marker) Monoclonal Antibody (MOC-31)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MOC-31 |
| Immunogen | Neuraminidase treated GLS-1 human small cell lung carcinoma cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Rat, Dog, or Cat.
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in epithelial tissues with a molecular weight of approximately 40 kDa.
It functions as a calcium-independent epithelial cell adhesion molecule and influences cell cycle, proliferation, and metabolism through induction of c-myc and cyclin A/E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth.
Overexpression of Ep-CAM is associated with enhanced epithelial proliferation and is a marker for tumors of epithelial lineage.
It is expressed on the baso-lateral surface of most simple epithelia and many carcinoma types, and helps distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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