Thermo Fisher Scientific CD335 (NKp46) Monoclonal Antibody (9E2), Alexa Fluor 488, eBioscience
인간 CD335(NKp46)를 인식하는 9E2 클론의 단일클론 항체로, Alexa Fluor 488 형광 표지. NK 세포 활성화 및 종양·바이러스 감염 세포 분석에 적합. Flow Cytometry용으로 검증된 시약이며, 4°C 암조건 보관.
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Thermo Fisher Scientific CD335 (NKp46) Monoclonal Antibody (9E2), Alexa Fluor 488, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.125 µg)/test
Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 488, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9E2 |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848430 |
Additional Formats
- APC
- eFluor 450
- Functional Grade
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Request custom conjugation
Product Specific Information
This 9E2 monoclonal antibody reacts with human CD335 (NKp46), a member of the natural cytotoxicity receptor family (including NKp30 and NKp44). CD335 is expressed on NK cells and plays a role in activating and expanding resting NK cells through interaction with dendritic cells, enabling the elimination of tumor and virus-infected cells such as influenza-infected targets. It also interacts with pancreatic beta cells, implicated in type I diabetes development.
The 9E2 antibody has been reported to induce cytotoxicity.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-diluted and validated for flow cytometry using human peripheral blood cells at 5 µL (0.125 µg) per test (final volume 100 µL).
Excitation: 488 nm
Emission: 519 nm
Laser: Blue Laser
Target Information
NKp46 (CD335, NCR1) is a cytotoxicity-activating receptor contributing to the enhanced efficiency of activated natural killer (NK) cells in mediating tumor cell lysis. NKp46 consists of two Ig-like domains assembled similarly to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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