Thermo Fisher Scientific GPM6A Polyclonal Antibody
Human GPM6A 단백질을 인식하는 토끼 폴리클로날 항체로, 면역조직화학(IHC) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공됩니다. 신경 분화 및 시냅스 형성 연구용으로 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GPM6A (Product #RP-91159) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642147 |
Product Specific Information
Immunogen sequence:
YFNLWTICRN TTLVEGANLC LDLRQFGIVT IGEEKKICTV SENFLRMCES TELN
Ortholog identity:
- Mouse: 96%
- Rat: 98%
Target Information
Neuronal membrane glycoprotein M6-a is a protein encoded by the GPM6A gene in humans.
This protein is involved in neuronal differentiation, including migration of neuronal stem cells, and plays a role in neuronal plasticity. It contributes to neurite and filopodia outgrowth, filopodia motility, and possibly synapse formation.
GPM6A-induced filopodia formation involves MAPK and Src signaling pathways. It may also be associated with NGF-dependent Ca²⁺ influx and regulation of endocytosis and intracellular trafficking of GPCRs, enhancing internalization and recycling of mu-type opioid receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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