Thermo Fisher Scientific E-selectin Monoclonal Antibody (C126C10B7)

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent
• Publications: Refer to component ID

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: —
• Publications: 1 publication available

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent
• Publications: 2 publications available

Miscellaneous PubMed (Misc)

• Tested Dilution: —
• Publications: 2 publications available

Product Specifications

Target Information

Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. Leukocyte adhesion also occurs in capillaries and small venules throughout the body following inflammation onset. This immediate response involves a cascade of adhesion receptors, including members of the selectin and immunoglobulin superfamilies at the endothelial surface.

E-selectin (CD62E) is an endothelial cell-specific C-type lectin expressed only after activation by proinflammatory cytokines. In vitro studies show that IL-1, TNFα, and bacterial components such as lipopolysaccharides induce E-selectin transcription via an NFκB-dependent signaling cascade. E-selectin is associated with blood vessel endothelium in various inflammatory contexts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.