Thermo Fisher Scientific APS Polyclonal Antibody
Human APS 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. B-cell 및 인슐린 신호전달 연구용으로 활용 가능.
- 판매단위
- pk
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Thermo Fisher Scientific APS Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human APS. Recombinant protein control fragment (Product #RP-99507). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638097 |
Product Specific Information
- Immunogen sequence: RDKWTRRLRL SRTLAAKVEL VDIQREGALR FMVADD
- Highest antigen sequence identity: Mouse – 97%, Rat – 97%
Target Information
APS (adapter protein with Pleckstrin homology and Src homology 2 domains) is a member of the Lnk family and functions as an adaptor protein involved in B-cell signaling, insulin signaling, and cytoskeletal reorganization. It is tyrosine phosphorylated by JAK2, KIT, and other kinases during B-cell receptor stimulation by various cytokines, chemokines, and leukokines. APS inhibits the JAK-STAT pathway in collaboration with c-Cbl. It is located in the cytoplasm of pre-PDGF stimulated cells and translocates to the plasma membrane and peripheral regions upon PDGF stimulation. APS is expressed in B-cells and mast cells within hematopoietic cell lines and in tissues such as spleen, prostate, testis, uterus, small intestine, and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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