Thermo Fisher Scientific MGMT Monoclonal Antibody (OTI6G6), TrueMAB
MGMT 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC 분석에 적합합니다. 인간 MGMT 전체 길이 재조합 단백질을 면역원으로 사용하였으며, 고순도 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6G6 |
| Immunogen | Full length human recombinant protein of human MGMT produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein also protects normal cells against the genotoxic and carcinogenic effects of DNA alkylation. MGMT removes alkyl groups introduced in the O6 position of guanine, contributing to alkylating drug resistance. Expression levels vary depending on cell and tissue type, species, and growth characteristics, and activity differs among tumor groups and within specific tumor types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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