Thermo Fisher Scientific Cyclin B1 (G2- and M-phase Cyclin) Monoclonal Antibody (CCNB1/1098)
Cyclin B1 단백질을 인식하는 Mouse monoclonal antibody로, 세포주기 G2/M 단계 연구에 적합. Human 및 Mouse 시료에 반응하며, IHC(P), IHC(PFA), ICC/IF에서 사용 가능. 단백질 A/G 정제, 보존제 없음, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CCNB1/1098 |
| Immunogen | Recombinant human full-length CCNB1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cyclins bind to and regulate the activity of cyclin-dependent protein kinases (CDKs). Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis and is essential for controlling the cell cycle at the G2/M transition. It complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts exist: one constitutive and one cell cycle-regulated, predominantly expressed during G2/M phase. Cyclin B1 accumulates during G2 and is degraded at the end of mitosis via APC-dependent mechanisms. Overexpression has been observed in various cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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