Thermo Fisher Scientific RPRD1B Polyclonal Antibody
Rabbit polyclonal antibody targeting human RPRD1B protein for WB, IHC, and IP applications. Provides high specificity and sensitivity. Suitable for studying RNA polymerase II regulation and cell cycle-related gene expression. For research use only.
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Thermo Fisher Scientific RPRD1B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:10,000 |
| Immunoprecipitation (IP) | 1–4 µL/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human RPRD1B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2866883 |
Target Information
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and participates in dephosphorylation of the CTD by RPAP2.
Acts as a transcriptional regulator enhancing expression of CCND1. Promotes RNA polymerase II binding to the CCND1 promoter and termination region before the poly-A site, but decreases binding after the poly-A site.
Prevents RNA polymerase II from reading through the 3′ end termination site and may facilitate recruitment back to the promoter via chromatin loop formation.
Enhances transcription of other cell cycle-related genes such as CDK2, CDK4, CDK6, and Cyclin-E, but not CDKN1A, CDKN1B, or Cyclin-A. Promotes cell proliferation.
(Source: UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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