Thermo Fisher Scientific ROR1 Polyclonal Antibody, Biotin
ROR1 단백질을 인식하는 Biotin 결합 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP에 적합. Human, Mouse, Rat 등 다양한 종에 반응. 고순도 Affinity chromatography 정제 및 안정적인 액상 형태로 연구용에 최적화됨.
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Thermo Fisher Scientific ROR1 Polyclonal Antibody, Biotin
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to C-terminal amino acids 900–918 on Human ROR1 protein. Peptide was coupled to a carrier protein using heterobifunctional cross linker. Sequence: TVKGNKSQKPYKIDSKQAS |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated surface protein predominantly expressed during embryogenesis, where it plays roles in organ morphogenesis, nervous system development, and neural progenitor cell maintenance. It is virtually absent from normal adult tissues except in immature B cell precursors (hematogones) and adipocytes. ROR1 is notably overexpressed in several malignancies, including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, and lung adenocarcinoma.
Initially identified in neuroblastoma cell lines as an orphan receptor tyrosine kinase, ROR1 and its homolog ROR2 were named for their unknown ligands. Wnt-5a has since been proposed as a ligand, and ROR1 may act as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through Wnt-5a interaction and TCL1-mediated AKT activation. ROR1 is expressed as a glycoprotein with extracellular Ig-like, Frizzled, and Kringle domains, and an intracellular tyrosine kinase domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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