Thermo Fisher Scientific ROR1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated surface protein predominantly expressed during embryogenesis, where it plays roles in organ morphogenesis and nervous system development. It is virtually absent from normal adult tissues except for low-level expression in immature B cell precursors and adipocytes. ROR1 is overexpressed in several malignancies, including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, and lung adenocarcinoma.

ROR1 was first identified during PCR-based cloning of a human neuroblastoma cell line searching for tyrosine kinases similar to Trk neurotropic receptors. Along with ROR2, it was classified as an orphan receptor due to the absence of a known ligand. Wnt-5a has been suggested as a candidate ligand, and ROR1 may function as a pseudokinase promoting proliferation and resistance to apoptosis in cancer cells through Wnt-5a interaction and TCL1-mediated AKT activation. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin-like, Frizzled, and Kringle domains, and an intracellular tyrosine kinase domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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