Thermo Fisher Scientific RPL7A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
EAIRTNYNDR YDEIRRHWGG NVLGPKSVAR IAKLE

Target Information

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.
This gene encodes a ribosomal protein that is a component of the 60S subunit and belongs to the L7AE family of ribosomal proteins. It can interact with nuclear hormone receptors, including the thyroid hormone receptor, and inhibit their ability to transactivate by preventing their DNA binding.
This gene is part of the surfeit gene cluster, co-transcribed with several small nucleolar RNA genes (U24, U36a, U36b, U36c). It can rearrange with the trk proto-oncogene to form the chimeric oncogene trk-2h, producing an oncoprotein combining the N terminus of ribosomal protein L7A with the receptor tyrosine kinase domain of trk.
As typical for ribosomal protein genes, multiple processed pseudogenes of this gene are dispersed throughout the genome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.