Thermo Fisher Scientific BTRC Recombinant Rabbit Monoclonal Antibody (2Z4D4)
Thermo Fisher Scientific의 BTRC Recombinant Rabbit Monoclonal Antibody (2Z4D4)는 인간, 마우스, 랫트 반응성을 가지며 HEK293 세포에서 발현된 재조합 단일클론 항체입니다. Western blot, IHC, ELISA에 적합하며 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2Z4D4 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human beta-TrCP/BTRC (NP_378663.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093920 |
Product Specific Information
Immunogen sequence:
MDPAEAVLQE KALKFMCSMP RSLWLGCSSL ADSMPSLRCL YNPGTGALTA FQNSSEREDC NNGEPPRKII PEKNSLRQTY NSCARLCLNQ ETVCLASTAM
Target Information
This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. F-box proteins form part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex, functioning in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes:
- Fbws (containing WD-40 domains)
- Fbls (containing leucine-rich repeats)
- Fbxs (containing other protein-protein interaction modules or no recognizable motifs)
The encoded protein belongs to the Fbws class and contains multiple WD-40 repeats. It is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2, and Drosophila Slimb proteins. It interacts with HIV-1 Vpu, connecting CD4 to the proteolytic machinery, and associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs. It likely functions in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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