Thermo Fisher Scientific Human TIGAR-TAT Recombinant Protein, PeproTech
Recombinant Human TIGAR-TAT 단백질로, E. coli에서 발현된 31.6 kDa TAT-fusion 형태입니다. TIGAR 활성으로 세포 내 F-2,6-BP를 감소시켜 NADPH 생성을 증가시키며, U2OS 세포의 산화 스트레스 유도 세포사멸을 억제합니다. 연구용으로만 사용됩니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publication for details
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | ARFALTVVRH GETRFNKEKI IQGQGVDEPL SETGFKQAAA AGIFLNNVKF THAFSSDLMR TKQTMHGILE RSKFCKDMTV KYDSRLRERK YGVVEGKALS ELRAMAKAAR EECPVFTPPG GETLDQVKMR GIDFFEFLCQ LILKEADQKE QFSQGSPSNC LETSLAEIFP LGKNHSSKVN SDSGIPGLAA SVLVVSHGAY MRSLFDYFLT DLKCSLPATL SRSELMSVTP NTGMSLFIIN FEEGREVKPT VQCICMNLQD HLNGLTETRG GGYGRKKRRQ RRR |
| Tag | TAT-fusion |
| Molecular Weight | 31.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥95% by SDS-PAGE and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Pretreatment with TIGAR-TAT (0.1–5.0 µg/ml, 4 hrs) protects U2OS cells from hydrogen peroxide-induced apoptosis |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human TIGAR-TAT expressed in E. coli is a 31.6 kDa protein containing 283 amino acid residues, including the 269 residues of full-length TIGAR fused to a 14-residue C-terminal peptide containing the TAT transduction domain (GGGYGRKKRRQRRR).
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2,6-bisphosphate (F-2,6-BP) to fructose-6-phosphate and inorganic phosphate.
F-2,6-BP activates 6-phosphofructose-1 kinase, the rate-limiting enzyme of glycolysis. By lowering intracellular F-2,6-BP, TIGAR expression increases glucose processing via the pentose phosphate pathway, enhancing NADPH production.
Protein transduction using TAT fusion proteins offers an alternative method for introducing transcription factors and other intracellular proteins into primary or transformed cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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