Thermo Fisher Scientific CD4 Monoclonal Antibody (4B12)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10-1:100

View 1 publication 1 publication

Immunohistochemistry (IHC)

-

View 33 publications 33 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:20

View 9 publications 9 publications

Immunohistochemistry (PFA fixed) (IHC (PFA))

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

-

View 5 publications 5 publications

Flow Cytometry (Flow)

1:2

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Fruit fly, Human, Mouse, Pig

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

4B12

Immunogen

Stimulated human leukocytes if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD4,uniProtId:P01730-1,ncbiNodeId:9606,antigenRange:1-458,antigenLength:458,antigenImageFileName:MA5-12259_CD4_P01730-1_House_mouse.svg,antigenImageFileNamePDP:MA5-12259_CD4_P01730-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_10989399

Product Specific Information

MA5-12259 targets CD4 in IHC (P), WB and FACS applications and shows reactivity with Human samples.

The MA5-12259 immunogen is stimulated human leukocytes.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.