Thermo Fisher Scientific TMC7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TMC7. Recombinant protein control fragment (Product #RP-90832). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TMC7,uniProtId:Q7Z402-1,ncbiNodeId:9606,antigenRange:27-143,antigenLength:723,antigenImageFileName:PA5-56158_TMC7_Q7Z402-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56158_TMC7_Q7Z402-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648533

Product Specific Information

Immunogen sequence: LDSSCFSSPP VNFLQELPSY RSIARRRTTV HSRDKQSGTL LKPTDSYSSQ LEDRIAENLS SHSLRNYALN ISEKRRLRDI QETQMKYLSE WDQWKRYSSK SWKRFLEKAR EMTTHLE

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.

Target Information

TMC7 (Transmembrane channel-like protein 7) is a 723 amino acid protein that is a member of the TMC protein family. All TMC genes encode transmembrane proteins with intracellular amino- and carboxy- termini and at least eight membrane spanning domains. Therefore, TMC7 is a multi-pass membrane protein that may regulate or function as an ion channel or transporter. The gene encoding TMC7 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn`s disease, which is a gastrointestinal inflammatory condition.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.