Thermo Fisher Scientific Phospho-GAB2 (Tyr643) Polyclonal Antibody
Phospho-GAB2 (Tyr643) 특이적 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 IHC(Paraffin) 분석에 적합하며, 고순도 Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
- Publications: View references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 643 (V-D-Y(p)-V-Q) derived from Human Gab2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554386 |
Product Specific Information
- Suggested positive control for Western blot: NIH-3T3 cells
- Suggested positive control for IHC: Human brain tissue
Target Information
This gene belongs to the GRB2-associated binding protein (GAB) family. These proteins contain a pleckstrin homology (PH) domain and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters to transmit signals in response to cytokine and growth factor receptor stimulation, as well as T- and B-cell antigen receptor activation. The encoded protein is a key activator of phosphatidylinositol-3 kinase following high-affinity IgE receptor activation. Two alternatively spliced transcripts encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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