Thermo Fisher Scientific Claudin 3 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human Claudin 3.

Target Information

Claudin 1–8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell-to-cell contact that act as molecular gaskets to prevent leakage of ions and water between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit distinct Claudin compositions. Differential expression of this gene has been observed in various malignancies, including breast, ovarian, liver, urinary, prostate, lung, head and neck, and thyroid cancers. Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.