Thermo Fisher Scientific CD21 Polyclonal Antibody
Thermo Fisher Scientific의 CD21 Polyclonal Antibody는 인간 CD21 단백질을 인식하는 토끼 IgG 항체로, WB, IHC, ELISA, IP 등 다양한 응용에 적합합니다. 보존제가 없으며, 장기 보관 시 -20°C에서 냉동 보관을 권장합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:10,000 |
| ELISA | 1:25,000–1:50,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CD21 protein (Met1–Arg971) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787805 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human CD21.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigens.
It plays a role in the uptake and retention of immunocomplexes, survival of memory B cells, and maintenance of the humoral immune response.
CD21 also serves as a receptor for Epstein-Barr virus and participates in prion targeting to follicular dendritic cells.
A soluble form (sCD21) retains ligand-binding ability.
CD21 interacts with CD23 and associates with CD19, CD81, and Leu13 to form a signal-transduction complex involved in B cell activation.
Genetic variations in CD21 are linked to susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternatively spliced transcript variants encoding different isoforms of CD21 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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