Thermo Fisher Scientific UFD1L Polyclonal Antibody
Rabbit polyclonal antibody against human UFD1L for ICC/IF applications. Affinity-purified and supplied in PBS with glycerol. Suitable for research on ubiquitin-mediated proteolysis. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UFD1. Recombinant protein control fragment (Product # RP-105824) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790292 |
Product Specific Information
Immunogen sequence: RLNITYPMLF KLTNKNSDRM THCGVLEFVA DEGICYLPHW MMQNL
Target Information
Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine residues on target proteins, marking them for degradation by the 26S proteasome. The UFD1 protein, originally identified in yeast and later in humans as UFD1L, regulates this process by modulating the degradation of Ub-fusion proteins. Mutations in the UFD1 gene are associated with CATCH22 syndrome, which includes cardiac defects, cleft palate, and hypocalcemia, suggesting a developmental role for this pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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