Thermo Fisher Scientific AP2M1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (98%), Dog (100%), Pig (98%), Chicken (98%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (100%).
• Positive Control: HepG2, mouse brain.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping during the acidification of endosomes and lysosomes.
AP2M1 associates with the HIV-1 protein Nef, suggesting that Nef may utilize the AP-2 complex to enhance endocytosis of CD4 and class I MHC.
AP2M1 may also regulate intracellular trafficking and function of CTLA-4 protein. At least two isoforms of AP2M1 are known to exist.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.