Thermo Fisher Scientific MMP15 Polyclonal Antibody
MMP15 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 면역세포염색에 적합하며, 사람과 생쥐 시료에서 반응. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
- 카탈로그번호
- PA599176
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MMP15 (Accession P51511), corresponding to amino acid residues V626–V669 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818109 |
Product Specific Information
Antibody detects endogenous levels of total MMP15.
Target Information
Matrix metalloproteinases (MMPs) are enzymes involved in matrix degradation. Among sixteen MMP family members, ten are soluble, while MT-MMPs are membrane-bound proteins. MT1-MMP, MT2-MMP, MT3-MMP (also known as MMP14, MMP15, MMP16) contain a C-terminal transmembrane domain anchoring them to the cell surface and have an 8 amino acid insert in their catalytic domain.
MT1-MMP activates progelatinase A (MMP-2) and progelatinase B. MT2-MMP plays a minor role in activating pro-MMP-2 in breast carcinomas. Coexpression of MT1-MMP and MT2-MMP in advanced breast carcinomas suggests involvement of MT2-MMP in metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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