Thermo Fisher Scientific Cdc23 Polyclonal Antibody
Thermo Fisher Scientific의 Cdc23 폴리클로날 항체는 인간, 마우스, 랫트에 반응하며 WB 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 1 mg/mL 농도이며 장기 보관 시 -20°C에서 안정적입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Cdc23 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1–2 µg/mL
- Immunocytochemistry (ICC/IF): 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the center of human APC8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156602 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-20949 can be used with blocking peptide PEP-1063
Target Information
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s), and the ubiquitin-protein ligases (E3s).
Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins containing destabilizing N-terminal residues, leading to their ubiquitination and degradation. Mice lacking Ubr2 are infertile due to defects in male meiosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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