Thermo Fisher Scientific Cdc23 Polyclonal Antibody

Thermo Fisher Scientific Cdc23 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1–2 µg/mL
• Immunocytochemistry (ICC/IF): 5 µg/mL

Product Specifications

Product Specific Information

• Suggested positive control: K562 cell lysate
• PA5-20949 can be used with blocking peptide PEP-1063

Target Information

Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s), and the ubiquitin-protein ligases (E3s).
Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins containing destabilizing N-terminal residues, leading to their ubiquitination and degradation. Mice lacking Ubr2 are infertile due to defects in male meiosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.