Thermo Fisher Scientific JNK1 Polyclonal Antibody
인간 JNK1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 보존제가 없는 액상 형태로 제공되며, Protein A 및 항원 친화 크로마토그래피로 정제됨. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- PA581218
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:250–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:300–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human JNK1/MAPK8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788447 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to prevent contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human JNK1.
Target Information
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is a crucial mediator of insulin resistance and obesity and belongs to the MAPK superfamily of stress-activated protein kinases.
MAPKs are serine-threonine protein kinases activated in response to various extracellular stimuli, mediating signal transduction from the cell surface to the nucleus.
JNK participates in cellular processes such as proliferation, differentiation, transcription regulation, and development. JNK pathways are activated by stress and inflammatory signals.
JNK is expressed as ten isoforms due to differential mRNA splicing, with JNK1 and JNK2 being predominant.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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