Thermo Fisher Scientific Alpha Sarcoglycan Polyclonal Antibody
Alpha Sarcoglycan 단백질을 검출하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 최적화됨. 인체, 마우스, 랫트 시료에 반응하며, 고순도 친화 크로마토그래피 정제. PBS 기반 완충액에 50% 글리세롤 포함, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SGCA (Accession Q16586), corresponding to amino acid residues P167–D217 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854268 |
Product Specific Information
Antibody detects endogenous levels of total SGCA.
Target Information
The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunits — alpha, beta, gamma, and delta — form a complex on the skeletal muscle cell surface. Genetic defects in any of these proteins cause the loss or reduction of the entire sarcoglycan complex, leading to autosomal recessive muscular dystrophy (sarcoglycanopathy).
In smooth muscle, beta- and delta-sarcoglycans associate with epsilon-sarcoglycan, a glycoprotein homologous to alpha-sarcoglycan. A complete deficiency in delta-sarcoglycan is known to cause the Syrian hamster BIO.14 cardiomyopathy.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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