Thermo Fisher Scientific ATRX Polyclonal Antibody
ATRX 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human 및 Mouse 시료에 반응하며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관되며, -20°C에서 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATRX (Accession P46100), corresponding to amino acid residues T125–G175 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853798 |
Product Specific Information
This antibody detects endogenous levels of total ATRX.
Target Information
ATRX encodes a protein containing an ATPase/helicase domain and belongs to the SWI/SNF family of chromatin remodeling proteins. Mutations in this gene are associated with X-linked mental retardation (XLMR) often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations can alter DNA methylation patterns, linking chromatin remodeling, DNA methylation, and gene expression during development. ATRX undergoes cell cycle-dependent phosphorylation, regulating its nuclear matrix and chromatin association, implicating it in gene regulation during interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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