Thermo Fisher Scientific RARA Monoclonal Antibody (2D2)
RARA 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, ELISA에 적합합니다. 인간 시료 반응성으로 높은 특이성과 재현성을 제공합니다. PBS buffer에 보관되며, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific RARA Monoclonal Antibody (2D2)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1.2 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D2 |
| Immunogen | RARA (NP_000955, 315–424 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QLLPLEMDDA ETGLLSAICL ICGDRQDLEQ PDRVDMLQEP LLEALKVYVR KRRPSRPHMF PKMLMKITDL RSISAKGAER VITLKMEIPG SMPPLIQEML ENSEGLDTLS
Target Information
RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to ligands (all-trans or 9-cis retinoic acid) and regulate gene expression in various biological processes.
RXR/RAR heterodimers bind to retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites (DR1–DR5).
In absence of ligand, RXR-RAR heterodimers associate with transcription corepressors that induce histone acetylation, chromatin condensation, and transcriptional suppression. Upon ligand binding, corepressors dissociate and coactivators bind, leading to transcriptional activation.
RARA plays an essential role in retinoic acid-induced germ cell development during spermatogenesis and promotes survival of early spermatocytes. In Sertoli cells, RARA supports development of early meiotic prophase spermatocytes. Together with RARG, it is required for skeletal growth, matrix homeostasis, and growth plate function. RARA regulates target gene expression by recruiting chromatin complexes containing KMT2E/MLL5 and mediates retinoic acid-induced granulopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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