Thermo Fisher Scientific MFN1 Monoclonal Antibody (OTI2E4), TrueMAB
인간 MFN1 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합합니다. 고순도의 액상 포맷으로 제공되며, PBS/BSA/glycerol 완충액에 보존됩니다. 미토콘드리아 융합 및 세포사멸 연구에 활용 가능합니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 209–469 of human MFN1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes.
MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion, which is essential for embryonic development.
When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in regulating the activation of Bax on the outer mitochondrial membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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