Thermo Fisher Scientific PRKAR2A Recombinant Rabbit Monoclonal Antibody (ARC0860)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0860

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 312-404 of human PKA RIIα (PRKAR2A) (P13861) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PRKAR2A,uniProtId:P13861-1,ncbiNodeId:9606,antigenRange:312-404,antigenLength:404,antigenImageFileName:MA5-35415_PRKAR2A_P13861-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35415_PRKAR2A_P13861-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849316

Product Specific Information

Immunogen sequence: SRTKSNKDGG NQEVEIARCH KGQYFGELAL VTNKPRAASA YAVGDVKCLV MDVQAFERLL GPCMDIMKRN ISHYEEQLVK MFGSSVDLGN LGQ

Target Information

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of AMPK.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.