Thermo Fisher Scientific ORC1 Monoclonal Antibody (TK 1/2)
Xenopus ORC1 단백질을 검출하는 마우스 단클론 항체. Western blot 및 Immunoprecipitation에 최적화된 연구용 시약. Recombinant full length protein을 면역원으로 사용하며, Protein A로 정제된 액상 형태. 장기보관 시 -20°C에서 보관 권장.
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Thermo Fisher Scientific ORC1 Monoclonal Antibody (TK 1/2)
Applications
- Western Blot (WB): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Xenopus |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TK 1/2 |
| Immunogen | Recombinant full length protein (Xenopus laevis) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1959133 |
Product Specific Information
MA1-90545 detects ORC1 from Xenopus laevis samples.
Target Information
The origin recognition complex (ORC) is a highly conserved six-subunit protein complex essential for the initiation of DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.
The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cycle, controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is selectively phosphorylated during mitosis and interacts with MYST histone acetyltransferase 2 (MyST2/HBO1), involved in transcription silencing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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