Thermo Fisher Scientific TLR7 Polyclonal Antibody
Human TLR7 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P)에서 1:20~1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제됨. 4°C 단기 보관, -20°C 장기 보관 권장. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5111492
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human TLR7. Recombinant protein control fragment (Product #RP-101590) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2856902 |
Product Specific Information
Immunogen sequence:
MLNFTKNLKV LQKLMMNDND ISSSTSRTME SESLRTLEFR GNHLDVLWRE GDNRYLQLFK NLLKLEELDI SKNSLSFLPS GVFDGMPPNL KNL
Target Information
TLR7 is a highly conserved membrane protein belonging to the Toll-like receptor (TLR) family, containing 27 leucine-rich repeats (LRR) and a TIR domain. It plays a key role in pathogen recognition and activation of innate immunity.
TLR7 is activated by single-stranded RNA viruses such as influenza virus and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and is located near TLR8.
Through MyD88 and TRAF6, TLR7 leads to NF-kappaB activation, cytokine secretion, and inflammatory responses. It recognizes pathogen-associated molecular patterns (PAMPs) on infectious agents and mediates cytokine production necessary for effective immune responses.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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