Thermo Fisher Scientific LATH Polyclonal Antibody
Rabbit polyclonal antibody recognizing human LATH protein. Suitable for IHC(P) and ICC/IF applications. Supplied as liquid, 1 mg/mL concentration. Recommended storage at -20 °C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human LATH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20 °C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555318 |
Target Information
The PLUNC family of proteins are encoded by genes located on chromosome 20 and are believed to play a role in the innate immune response in the mouth, nose, and lungs. As a member of this family, BASE (breast cancer and salivary gland-expressed protein) is a 179-amino-acid secreted protein named for its expression pattern. Due to its 63% sequence similarity with the related protein Latherin, BASE is suggested to be a major component in sweat secretions with surfactant properties that lower surface tension. The expression of BASE in many breast cancer cell lines indicates its potential as a diagnostic marker. The gene encoding BASE is highly estrogen-repressed, suggesting expression is dependent on HNF-3α and estrogen-mediated repression via ERα.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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