Thermo Fisher Scientific Phospho-Leptin Receptor (Tyr1141) Polyclonal Antibody
Phospho-Leptin Receptor (Tyr1141) 항체로 인간 및 마우스 시료에 반응. Western blot 및 ELISA에 적합. 항원 친화 크로마토그래피로 정제된 Rabbit Polyclonal IgG. PBS 기반 완충액에 BSA와 글리세롤 포함, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Ob-R around the phosphorylation site of Y1141 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608697 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily that plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of OB-R by leptin triggers downstream signaling through the JAK/STAT pathway. OB-R can homo-dimerize, and several isoforms differing in length and signaling capabilities have been reported. The OB-R long form is expressed in the choroid plexus and hypothalamus, which regulate satiety and energy expenditure. Mutations in OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and increased adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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