Thermo Fisher Scientific Phospho-MYPT1 (Ser668) Polyclonal Antibody
인간 MYPT1 Ser668 인산화 부위를 인식하는 Rabbit Polyclonal 항체입니다. Western blot에 적합하며, 고순도의 Affinity chromatography로 정제되었습니다. 액상 형태로 보존되며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:1,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Ser668 of human MYPT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 147 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982028 |
Target Information
Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is one of the subunits regulating the interaction of actin and myosin downstream of Rho GTPase. RhoA, in its active GTP-bound form, interacts with MYPT1 to modulate myosin light chain (MLC) phosphorylation, influencing smooth muscle contraction and cytoskeletal dynamics in nonmuscle cells. Rho-associated kinase (Rho-kinase) phosphorylates and inactivates MYPT1, thereby inhibiting myosin phosphatase activity. Multiple transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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