Thermo Fisher Scientific FOXJ1 Polyclonal Antibody
Human FOXJ1 단백질에 특이적인 Rabbit Polyclonal Antibody. IHC(P)에서 1:500~1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. FOXJ1 관련 자가면역 및 섬모 형성과 관련된 연구에 적합.
- 카탈로그번호
- PA552189
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FOXJ1. Recombinant protein control fragment (Product # RP-102512) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2641716 |
Product Specific Information
Immunogen sequence:
PREKDEPGKG GFWRIDPQYA ERLLSGAFKK RRLPPVHIHP AFARQAAQEP SAVPRAGPLT VNTEAQQLLR EFEEATGEAG WGAGEGRLGH KRKQPLPKRV AKVPRPPSTL LPTPEEQGEL EPLKG
- Highest antigen sequence identity to orthologs:
- Mouse: 91%
- Rat: 29%
Target Information
Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and spontaneous autoimmunity by repressing NF-κB activity. It also inhibits the humoral immune response in B cells. FOXJ1 deficiency in B cells leads to spontaneous and enhanced germinal center formation and is linked to pathogenic autoantibody development and heightened immunization responses. Abnormal FOXJ1 expression may be associated with autoimmune and inflammatory diseases.
FOXJ1 is also required for cilia formation and left-right axis determination by increasing calpastatin expression, a protein essential for basal body anchoring to the apical cytoskeleton. Its expression may serve as an early marker of epithelial cell differentiation, recovery, and function.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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