Thermo Fisher Scientific IFIT3 Polyclonal Antibody
IFIT3 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot 및 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 인간 반응성, 액체 형태, 4°C 보관.
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Thermo Fisher Scientific IFIT3 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 350–400 of human Interferon-induced protein with tetratricopeptide repeats 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee
Target Information
IFN-induced antiviral protein which acts as an inhibitor of cellular and viral processes including cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by bridging TBK1 to MAVS, leading to activation of TBK1 and phosphorylation of IRF3. Phosphorylated IRF3 translocates into the nucleus to promote antiviral gene transcription. Exhibits antiproliferative activity via up-regulation of CDKN1A/p21 and CDKN1B/p27. IFIT3 sequesters COPS5 in the cytoplasm, increasing nuclear CDKN1B/p27 levels and upregulating CDKN1A/p21 by downregulating MYC. Can negatively regulate apoptotic effects of IFIT2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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